Endocrine Abstracts

Background: Struma ovarii is a germ cell tumor of the ovary containing ≥ 50% thyroid tissue and malignant struma ovarii (MSO) is a very rare disease containing papillary or follicular thyroid carcinomas (FTC). There is no consensus on optimal management for patients with MSO and no data on radioactive iodine (RAI) responsiveness. Here, we report two cases with RAI refractory MSO with NRAS mutation detected by next-generation sequencing (NGS). Case ...

Objective: Digital pathology is the process of scanning conventional slides and then digitally stitching consecutive images into digital slides that can be viewed, managed, and analyzed on a computer monitor. In this study, we evaluated the area of metastatic foci in cervical lymph node (LN) metastasis in application of digital pathology and prognostic implication for predicting structural recurrence in patients with papillary thyroid cancer (PTC).Method...

Background: The optimal initial surgical extent for medullary thyroid carcinoma (MTC) remains controversial. Aim of this study was to evaluate the ability of serum calcitonin and carcinoembryonic antigen(CEA) to predict the extent of surgery needed in the lateral neck in patients with MTC.Methods: This retrospective multicenter cohort study included data from patients with MTC surgically treated in the 6 tertiary medical centers in Korea from 1996 to 202...

Background: Unlike excellent prognosis of classical papillary thyroid carcinoma (cPTC), certain pathological subtypes of aggressive variants of PTC (AV-PTC) are considered to have poor clinical outcome. However, the evidence of unfavorable outcome of AV-PTC is not clear because previous studies did not control other confounding factors contributed to clinical outcomes.Methods: This retrospective cohort study initially included 4339 patients with cPTC and...

BackgroundAggressive variants of papillary thyroid carcinoma (PTC) have been described with increasing frequency and are associated with unfavorable clinical outcomes. However, limited data exists on the comprehensive genetic profile of these variants.MethodWe performed targeted next generation sequencing in 36 patients with aggressive variants of PTC and compared it to PTC from The Cancer Genome Atlas projec...